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Turmeric Plus

Supporting a Healthy Inflammatory Response   

 

Turmeric Plus  is a blend of proteolytic enzymes, polyphenols, and botanical extracts designed to promote a healthy inflammatory response and aid the body in breaking down specific proteins produced during natural inflammation.* Occasional inflammation is the body’s response to various traumas—physical, dietary, or environmental. Taken on an empty stomach, proteolytic enzymes assist in breaking down damaged tissue.*

Traditional Chinese and Ayurvedic medicine have utilized curcumin, ginger, and Boswellia for centuries to modulate the production of inflammatory compounds.* Phytonutrients in quercetin, rutin, resveratrol, and rosemary may protect cells from excess oxidative stress.* By supporting a healthy inflammatory response and antioxidant status, Turmeric Plus  may aid in treating inflammatory conditions, injuries, and postoperative tissue repair.*

Our bodies naturally create inflammation to deal with the multitude of traumas inflicted on a daily basis such as physical exertion, food sensitivities, and environmental exposures like pollution, heavy metals, and pesticides.  When we experience any insult, the immune system triggers the inflammatory cascade to begin the process of protection and clean up.

When the insults become chronic, this inflammatory cascade produces fibrinolytic proteins (enzymes) that become damaging to our cells, causing things such as pain, inflammation, and poor healing. Improving our bodies through proper lifestyle choices, therapeutic exercise, and removing toxic burden is important at decreasing the chronic inflammation that has become all too common today.

The Inflammatory Cascade

Our bodies naturally create inflammation to deal with the multitude of traumas inflicted on a daily basis such as physical exertion, food sensitivities, and environmental exposures like pollution, heavy metals, and pesticides.  When we experience any insult, the immune system triggers the inflammatory cascade to begin the process of protection and clean up. When the insults become chronic, this inflammatory cascade produces fibrinolytic proteins (enzymes) that become damaging to our cells, causing things such as pain, inflammation, and poor healing. Improving our bodies through proper lifestyle choices, therapeutic exercise, and removing toxic burden is important at decreasing the chronic inflammation that has become all too common today.

Why Turmeric Plus?

Turmeric, Ginger, Quercitin, and Resveratrol have all shown  to inhibit the COX-2 enzymes, which are pro-inflammatory.  The proteolytic enzymes when taken on an empty stomach help to break down damaged tissue, and promote a healthier response to inflammation in the body.  Rubin, Rosemary, and Resveratrol are antioxidant compounds that protect cells by limiting oxidative stress, which is a factor in activating inflammatory responses in the body.

 

Benefits:

  • Fosters a regular inflammatory response
  • Maintains joint health
  • Supports antioxidant status in the body
  • Aids the body’s repair process following injury
  • Promotes normal tissue repair postoperatively

 

Ingredient Highlights

InflammEnz™, a clinically researched proteolytic enzyme, is highly resistant to stomach acid, easily absorbed into the bloodstream from the small intestine.  InflammEnz™, a proprietary blend of clinically researched proteolytic enzymes, accelerates the body’s repair process for soft tissue injuries, traumas, and surgical wounds. The enzymes, including proteases, serratiopeptidase, trypsin, and chymotrypsin, activate alpha‑2‑macroglobulins, modulating the inflammatory cascade. This activation enhances immune cell activity, clears pro-inflammatory cytokines, and slows neutrophil migration.

The combination of trypsin and chymotrypsin targets acute phase reactants, shortening fibrinolytic shutdown and reducing inflammatory tissue destruction. Clinical trials demonstrate significant acceleration of soft tissue wound repair with InflammEnz™ supplementation, supporting the body’s repair process effectively.

Turmeric (Curcuma longa) has a history in Ayurvedic medicine for treating inflammatory conditions, thanks to its bioactive curcuminoids: curcumin, desmethoxycurcumin, and bisdemethoxycurcumin. These constituents exhibit anti-inflammatory and antioxidant properties, accelerating tissue repair and shortening the inflammatory phase. They inhibit the expression of TNF-α, IL-1, NF-κB, and kinase activity, inducing apoptosis of pro-inflammatory cells.

Curcumin supplementation significantly reduces inflammation and oxidative stress biomarkers, according to a systematic review. In animal models and human trials, curcumin demonstrates chondroprotective effects, alleviating pain and cartilage degeneration in conditions like joint arthritis and rheumatoid arthritis. Additionally, curcumin exhibits beneficial effects in intestinal inflammatory conditions, influencing microbial properties, immune cell functions, and cytokine profiles within the gastrointestinal tract.

Boswellin®- Boswellia serrata, known as Indian frankincense, contains boswellic acids utilized in Ayurvedic and contemporary medicine for inflammatory conditions, including arthritis. The β-boswellic acids in Boswellia serrata extract exhibit anti-inflammatory properties, attenuating mediators and oxidative stress in arthritis. Studies in collagen-induced arthritis and osteoarthritis (OA) demonstrate Boswellin®’s effectiveness in reducing 5-lipoxygenase activity and decreasing OA severity and metalloproteinases.

A pilot trial revealed oral Boswellin® supplementation significantly lowered hs-CRP levels, improved pain, and reduced stiffness in knee OA patients compared to a placebo over 120 days.

Ginger (Zingiber officinale) extract, rich in the bioactive gingerol, has been utilized for centuries due to its antioxidative, antiproliferative, and anti-inflammatory properties. In human chondrocytes, it suppresses IL-1B-induced expression of TNF-α, IL-6, and IL-8 by inhibiting inflammatory mitogen-activated protein kinase signaling pathways. In rat models of liver cancer, standardized ginger extract counteracts oxidative stress and inflammatory damage, restoring key antioxidant levels and preventing an increase in cyclooxygenase (COX)-2 and NF-κB in the liver.

Quercetin, rutin, resveratrol, and rosemary are polyphenols with demonstrated anti-inflammatory activity in human and animal studies. Resveratrol supplementation in individuals with rheumatoid arthritis (RA) suppressed pro-inflammatory markers, suggesting an anti-RA effect. Quercetin, in human chondrocytes and a rat model of osteoarthritis (OA), reduced ROS levels and inhibited inflammatory signaling pathways like NF-κB.

Rosemary’s major phenolic compound, carnosic acid, exhibits antioxidative and anti-inflammatory properties. Studies in RA demonstrated carnosic acid’s significant downregulation of pro-inflammatory cytokine expression, inhibition of osteoclastogenesis, and suppression of 5-lipoxygenase and PGE2, suggesting potential benefits for individuals with RA.

  • GMO-free

 

Support

Cytokine / Immune

 

Systems

Immune System 

Nervous System

 

Recommended Use

Take 2 capsules per day between meals or as directed by your health-care practitioner. For best results, this product should be taken on an empty stomach, approximately 1 hour before meals or several hours after.

 

What to Avoid

Warning: Not recommended for use by pregnant or lactating women.

 

$40.99 or $36.89 / month

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Additional information

Weight 6.1 oz
Dimensions 2 × 2 × 4 in
Size/Servings

60 capsules / 30 servings

Ingredients

InflammENZ Propietary Blend, Tumeric (Curcuma longa root), Boswellia (as Boswellin Extract- Boswellia serrata resin), Ginger Extract (Zingiber officinale root), Quercetin, Rubin, Rosemary Extract (Rosmarinus officinalis leaf), Trans Resveratrol ( Polyganum cuspidatum) cellulose capsule, microcrystalline cellulose, vegetable stearate, silicon dioxide.

FDA Disclaimer*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease“

Research

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2. InflammEnz™ Research. Enzymes Inc. https://www.enzymesinc.com/inflammenz‑research/. Accessed June 2, 2021.
3. pHysioProtease®. Kansas City, MO: Enzymes Inc. https://www.enzymesinc.com/physioprotease‑how‑it‑works/.
4. Brown SA, Coimbra M, Coberly DM, Chao JJ, Rohrich RJ. Oral nutritional supplementation accelerates skin wound healing: a randomized, placebo‑controlled, double‑arm, crossover study. Plast Reconstr Surg. 2004;114(1):237‑244. doi:10.1097/01.prs.0000128818.28425.52.
5. Lomax JE. The use of oral proteolytic enzymes in patients after undergoing blepharoplasty. Aesthet Surg J Open Forum. 1998;18(1):40‑41. doi:org/10.1016/S1090‑820X(98)80024‑1.
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and oxidative stress: a systematic review and meta‑analysis of randomized controlled trials. Phytother Res.2019;33(2):253‑262. doi:10.1002/ptr.6226.
9. Ansari MY, Ahmad N, Haqqi TM. Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother. 2020;129:110452. doi:10.1016/j.biopha.2020.110452.
10. Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta‑analysis of randomized clinical trials. J Med Food. 2016;19(8):717‑729.doi:10.1089/jmf.2016.3705.
11. Burge K, Gunasekaran A, Eckert J, Chaaban H. Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection. Int J Mol Sci. 2019;20(8):1912. doi:10.3390/ijms20081912.
12. Majeed M, Nujoma Y, Badmaev V, Parkash L. Boswellin® The Anti‑Inflammatory Phytonutrient. NJ: Nutriscience Publishers, Inc. 1996.
13. Nam DE, Kim OK, Shim TJ, Kim JH, Lee J. Effect of Boswellia serrata extracts on degenerative osteoarthritis in vitro and in vivo models. J Korean Soc Food Sci Nutr 20. 14;43(5):631‑640. https://www.e‑jkfn.org/journal/view.html?volume=43&number=5&spage=631.
14. Umar S, Umar K, Sarwar AH, et al. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine. 2014;21(6):847‑856. doi:10.1016/j.phymed.2014.02.001.
15. Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double‑blind, placebo‑controlled trial
to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res. 2019;33(5):1457‑1468. doi:10.1002/ptr.6338.
16. de Lima RMT, Dos Reis AC, de Menezes APM, et al. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]‑gingerol in cancer: a comprehensive review. Phytother Res. 2018;32(10):1885‑1907. doi:10.1002/ptr.6134.
17. Hamza AA, Heeba GH, Hamza S, Abdalla A, Amin A. Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway. Biomed Pharmacother. 2021;134:111102. doi:10.1016/j.biopha.2020.111102.
18. Sung S, Kwon D, Um E, Kim B. Could polyphenols help in the control of rheumatoid arthritis? Molecules.2019;24(8):1589. doi:10.3390/molecules24081589.
19. Bao TQ, Li Y, Qu C, Zheng ZG, Yang H, Li P. Antidiabetic effects and mechanisms of rosemary (Rosmarinus officinalis L.) and its phenolic components. Am J Chin Med. 2020;48(6):1353‑1368. doi:10.1142/S0192415X20500664.
20. Liu M, Zhou X, Zhou L, et al. Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast‑like synoviocytes, and collagen‑induced arthritis rats. J Cell Physiol. 2018;233(8):6291‑6303.doi:10.1002/jcp.26517.
21. Maione F, Cantone V, Pace S, et al. Anti‑inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions. Br J Pharmacol. 2017;174(11):1497‑1508.doi:10.1111/bph.13545.

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