Natto-Serra Enzyme Blend*

$63.99 or Original price was: $63.99.Current price is: $57.59. / month

Natto-Serra Enzyme Blend – a powerful fusion of proteolytic enzymes derived from Aspergillus oryzae and Aspergillus melleus fungi. This unique blend isn’t just a supplement; it’s your companion on the path to joint, cardiovascular, respiratory, and immune well-being. Let’s delve into the incredible world of proteolytic enzymes and how they dance harmoniously with your body.

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Proteolytic Enzymes for Well Being

Natto-Serra Enzyme Blend – a powerful fusion of proteolytic enzymes derived from Aspergillus oryzae and Aspergillus melleus fungi. This unique blend isn’t just a supplement; it’s your companion on the path to joint, cardiovascular, respiratory, and immune well-being. Let’s delve into the incredible world of proteolytic enzymes and how they dance harmoniously with your body.

Understanding Proteolytic Enzymes

Picture the term “proteolytic” as the conductor of a symphony – breaking down proteins (“proteo”) into individual amino acids. These enzymes aren’t mere players; they’re found abundantly in nearly every corner of your body. Your body produces them for digestion in the gastrointestinal tract, promoting digestive health. But the magic goes beyond; proteolytic enzymes from sources like Aspergillus fungi contribute to overall health by breaking down old cellular debris and proteins linked to trauma responses.

Healthy Inflammatory Response: Proteolytic enzymes play a vital role in supporting a healthy inflammatory process. They act like skilled cleanup crews, clearing away proteins involved in the immediate response and protective phase, aiding proper healing and recovery.

Cardiovascular Health:Your heart and blood vessels, sensitive to injury, benefit from these enzymes. They help maintain a healthy blood flow free from fibrous debris, ensuring optimal circulation and minimizing potential blockages.

Immune Health: The immune system’s constant battle against harmful toxins and organisms receives valuable support from proteolytic enzymes. By breaking down harmful proteins, these enzymes assist in the body’s defense against invaders.

Joint Health:  Scar tissue accumulation in joints can impede mobility. Proteolytic enzymes step in, degrading excess scar tissue composed of proteins, promoting joint function, and enhancing mobility.

Respiratory Health: Lungs, exposed to environmental toxins, may accumulate scar tissue and mucus. Proteolytic enzymes aid in keeping the lungs clear of foreign proteins, supporting a balanced inflammatory response for unencumbered breathing.



  1. Cardiovascular health
  2. Respiratory health
  3. Immune function
  4. Healthy joints
  5. A healthy inflammatory response
  6. Optimal digestion


Ingredient Highlights 

Nattozimes® is a blend of fungal proteolytic enzymes mimicking the fibrinolytic activity of nattokinase, found in Japanese natto. Natto, a traditional soy product, is esteemed for its cardiovascular benefits. Nattokinase, a potent fibrinolytic enzyme in Nattozimes®, may dissolve blood clots and aid cardiovascular health by inhibiting ACE and reducing blood pressure. Studies suggest it has thrombolytic effects, inhibiting platelet aggregation and preventing clot formation without adverse effects like aspirin. Nattokinase in Nattozimes® is orally bioactive and detectable in serum, supporting its efficacy after digestion. Supplementation may reduce fibrinogen levels, decreasing cardiovascular risk factors. Nattozimes® offers potential for preventing and treating thrombosis and embolism.

Serrazimes®, a patented ingredient, emulates serrapeptase, a proteolytic enzyme found in silkworms. With notable benefits for respiratory conditions, serratiopeptidase may enhance antibiotic effectiveness by disrupting bacterial biofilms. Beneficial for sinuses, lungs, and the immune system, it reduces mucus viscosity in chronic sinusitis. A double-blind RCT showed rapid relief for ear, nose, and throat disorders. In chronic airway disease, serrapeptase supplementation led to decreased sputum weight and cough frequency. Post-operatively, it reduces pain and swelling, especially after oral-facial surgery and wisdom tooth removal. Serratiopeptidase may also aid carpal tunnel syndrome and disrupt bacterial biofilms, potentially improving antibiotic sensitivity in fighting resistant infections.



*Heart Health

*Lung Health











Recommended Use

  • As a dietary supplement, take one capsule per day, or as directed by your health care practitioner. 

Additional Dosing Suggestions: 

  • Acute: 1 capsules 3-4x per day (away from meals)
  • Chronic: 1 capsules 2-3x per day (away from meals)
  • History of heart disease: 4 capsules per day (away from meals) 


Nattozimes® , Serrazimes®, vegetable cellulose, microcrystalline cellulose, rice bran, water.

Ingredient Partners 


What to Avoid 

Systemic proteases, such as those in Natto-Sera Enzyme Blend, are known to have antithrombotic properties. Individuals who suffer from clotting or bleeding disorders and who are being treated with antithrombotic medications (e.g., warfarin, coumadin, aspirin) may experience increased clotting times when using this product. Individuals with ulcers or who have had recent surgery should not Natto-Serra Enzyme Blend.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


1. Information on file with National Enzyme Company, Forsyth, Missouri.
2. Ero MP, Ng CM, Mihailovski T, Harvey NR, Lewis BH. A pilot study on the serum pharmacokinetics of nattokinase in humans following a single, oral, daily dose. Altern Ther Health Med. 2013 May-Jun;19(3):16-9.
3. Murakami K, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food. Food Funct. 2012 Jun;3(6):674-8.
4. Kim JY et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008
5. Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, Nakamuta H. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(11):1696-701.
6. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43.
7. Jang J-Y, Kim T-S, Cai J, et al. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Laboratory Animal Research. 2013;29(4):221-225.
8. Suzuki Y et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98.
9. Hsia CH et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 Mar;29(3):190-6.
10. Danielsen R, Onundarson PT, Thors H, Vidarsson B, Morrissey JH. Activated and total coagulation factor VII, and fibrinogen in coronary artery disease. Scand Cardiovasc J. 1998;32(2):87-95.
11. Tracy RP, Arnold AM, Ettinger W, Fried L, Meilahn E, Savage P. The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly: results from the cardiovascular health study. Arterioscler Thromb Vasc Biol. 1999 Jul;19(7):1776-83.
12. Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9.
13. Mazzone A et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-88.
14. Nakamura S et al. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep;8(3):316-20.
15. Tachibana M, Mizukoshi O, Harada Y, Kawamoto K, Nakai Y. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica. 1984;3(8):526-30.
16. Al-Khateeb TH, Nusair Y. Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. 2008 Mar;37(3):264-8.
17. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 1999 Dec;47(12):1170-2.
18. Longhi C et al. Protease treatment affects both invasion ability and biofilm formation in Listeria monocytogenes. Microb Pathog. 2008 Jul;45(1):45-52.
19. Elchinger PH et al. Effect of proteases against biofilms of Staphylococcus aureus and Staphylococcus epidermidis. Lett Appl Microbiol. 2014 Nov;59(5):507-13.
20. Artini M et al. Comparison of the action of different proteases on virulence properties related to the staphylococcal surface. J Appl Microbiol. 2013 Jan;114(1):266-77.

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