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Immune Support Probiotic*

(1 customer review)

Why Bacillus?

Spore-based strains such as Bacillus are vital to the food chain as they have the intrinsic ability to produce a multitude of enzymes, secretory proteins, antimicrobial compounds, vitamins, and carotenoids.* Spore-forming probiotics are soil-based microorganisms found in dirt and vegetation that possess the ability to surround themselves with durable coats of protein, allowing them to survive in hostile environmental conditions.

Unlike most traditional probiotics which are similar to those naturally found in the human GI tract (e.g., lactobacilli, bifidobacteria), spore-based probiotics are delivered as dormant spores. The endospores encapsulate the beneficial bacteria strains making them extremely stable and highly resistant to stomach acid’s low pH, resulting in delivery of more usable probiotics to the intestines where they then revert to active, growing bacteria.  These spore-forming bacilli are resistant to heat and ambient humidity, thus no refrigeration is required. The spores are also resistant to ultraviolet radiation, solvents, hydrogen peroxide, and enzymes.

Immune Support Probiotic is an evidence-supported diverse combination of 5 different bacillus strains, including:

  • 5 billion CFU Bacillus subtilis (DE111®)
  • 2 billion CFU Bacillus coagulans (Lactospore®) • 1 Billion CFU Bacillus coagulans (SNZ1969)
  • 100 million CFU Bacillus coagulans (Lacris-15) • 2 billion CFU Bacillus clausii (CSI-08)

 

Benefits:

  • Supports healthy GI functions
  • Promotes bowel regularity and digestive health
  • Supports a healthy GI microbial balance
  • Promotes healthy inflammatory and immune responses

 

Ingredient Highlights

 

Viability:

Bacillus subtilis DE111® is a probiotic spore that supports immune function and digestive health by fostering a healthy GI microbial environment.* With its unique spore-forming ability, it can withstand harsh conditions during transit to the large intestine, promoting robust propagation.* This property, along with its adaptability to a wide pH and temperature range, enhances its efficacy and stability.*

 

Clinical trials confirm B. subtilis DE111®’s successful proliferation in the human GI tract under normal physiological conditions. Studies with ileostomy samples show that the spore-forming probiotic can germinate in the small intestine shortly after ingestion.* In a double-blinded study, the treatment group displayed reduced acetylcholine levels and increased expression of immune-related proteins in the small intestine, indicating support for digestion, lipid metabolism, and immune health within hours of consumption.* Bacillus strains, including B. subtilis DE111®, have been linked to promoting healthy immune responses, demonstrating anti-inflammatory properties, aiding water and sodium absorption, and attenuating oxidative stress in the colon.*

 

In vitro studies comparing Bacillus and Lactobacillus strains reveal that Bacillus coagulans, a component of ProbioSpore™, exhibits double the survival rate of Lactobacillus bulgaricus. Moreover, B. subtilis DE111® shows over ten times greater survivability in simulated gastric and intestinal fluids, making it well-suited for inclusion in ProbioSpore™ due to its enhanced survivability under hostile environments.*

 

GI Function and Gut Microflora Balance:

  1. subtilis DE111® may stimulate the production of short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, with associated health benefits.* These metabolically active end-products, derived from microbial fermentation of dietary carbohydrates, promote a healthy gut barrier by enhancing mucin formation, antimicrobial peptides, and tight-junction proteins.*

 

SCFAs support an acidic intestinal pH, hinder pathogenic bacteria growth, aid GI motility, and foster healthy inflammatory responses.* Butyric acid, particularly, serves as the preferred fuel for colonocytes, promoting GI function and structure through normal cellular processes.* Positive alterations induced by Bacillus spp. may be clinically relevant for GI conditions such as ulcerative colitis.*

 

Intestinal Bacilli act as “guards” by secreting compounds like bacteriocins and lipopeptides, demonstrating antimicrobial and antiviral actions.* Additionally, Bacillus spp. probiotics, like Bacillus clausii, exhibit antimicrobial properties against cytotoxins, countering toxic effects from pathogens like Clostridium difficile and Bacillus cereus.* Animal studies with Bacillus subtilis strains show potential in attenuating dysbiosis, reducing intestinal inflammation, and promoting a balanced gut microflora, offering mitigation against gut mucosal damage associated with ulcerative colitis.*

 

Bowel Regularity:

Bacillus strains aid in promoting bowel regularity and frequency, potentially benefiting individuals with occasional constipation or diarrhea.* Clinical trials with B. subtilis DE111® demonstrated increased daily bowel movements and reduced fasting blood glucose levels.* Another study showed improved bowel health over 105 days of supplementation, as per the Bristol Stool Chart, compared to healthy controls.*

 

Bacillus coagulans Lactospore® significantly improved symptoms associated with diarrhea-predominant irritable bowel syndrome (IBS-D) in a 90-day trial, including bloating, vomiting, diarrhea, stool frequency, and abdominal pain.* Additionally, IBS patients with major depressive disorder reported improved quality of life with the same Bacillus coagulans spp., suggesting a potential link between intestinal bacteria and mental health through the gut-brain axis.*

 

Immune Function:

Bacillus spp. may enhance immune health.* Bacillus subtilis modulates cytokine release in human immunocompetent cells, elevating anti-inflammatory IL-10 and reducing pro-inflammatory cytokines IL-12, TNF-α, and IFN-γ.* In an animal model, a combination of probiotic B. coagulans and prebiotic inulin improved markers of rheumatoid arthritis, decreasing pro-inflammatory cytokines, fibrinogen, and serum amyloid A levels.*

 

A randomized intervention study showed that B. subtilis DE111® supplementation increased anti-inflammatory immune cell populations in subjects.* Comprehensive human clinical studies indicate that B. clausii may modulate genes related to inflammation, immunity, pathogen exposure, intestinal permeability, and cellular processes.*

 

In vitro data suggests spore-based Bacillus probiotics support digestive health by enhancing intestinal barrier function and reducing pro-inflammatory responses.* A trial with college athletes receiving DE111® showed a significant reduction in circulating pro-inflammatory cytokine TNF-α after 12 weeks of probiotic supplementation.*

 

Support

Digestion  

Immunity 

Systems

Gastrointestinal

Immune System 

 

Recommended Use

Take 1 capsule per day with a meal, or as directed by your health-care practitioner.

 

What to Avoid

Consult with your health-care practitioner about your specific circumstances and any questions you may have about this product.

 

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Additional information

Weight 4.6 oz
Dimensions 2.0 × 2.0 × 3.75 in
Ingredients

Bacillus coagulans, Bacillus subtilis (DE111*), Bacillus coagulans (SNZ1969), Bacillus coagulans (Lacris-15) , Bacillus clausii (CSI-08), microcrystalline cellulose, capsule ( hypromellose, water), medium chain triglyceride, silicon dioxide.

Ingredient Partners

DE111® and its logo are registered trademarks of Deerland Probiotics & Enzymes, Inc.
LactoSpore® and its logo are registered trademarks of Sabinsa Corporation.

Size/Servings

60 capsules / 60 servings

Research

1. Elshaghabee FMF, Rokana N, Gulhane RD, Sharma C, Panwar H. Bacillus as potential probiotics: status, concerns, and future perspectives. Front Microbiol. 2017;8:1490. doi:10.3389/fmicb.2017.01490
2. Mazhar S, Khokhlova E, Colom J, Simon A, Deaton J, Rea K. In vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®. Front Microbiol. 2022;13:1101144. doi:10.3389/fmicb.2022.1101144
3. Colom J, Freitas D, Simon A, et al. Acute physiological effects following Bacillus subtilis DE111 oral ingestion – a randomised, double blinded, placebo-controlled study. Benef Microbes. 2023;14(1):31-43. doi:10.3920/BM2022.0081
4. Colom J, Freitas D, Simon A, et al. Presence and germination of the probiotic Bacillus subtilis DE111® in the human small intestinal tract: a randomized, crossover, double-blind, and placebo-controlled study. Front Microbiol. 2021;12:715863. doi:10.3389/fmicb.2021.715863
5. Wong JMW, de Souza R, Kendall CWC, Emam A, Jenkins DJA. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40(3):235-243. doi:10.1097/00004836-200603000-00015
6. DE111® Bacillus subtilis. DE111 survivability in simulated in gastric and intestinal fluid. Deerland Probiotics and Enzymes; 2017
7. Shinde T, Vemuri R, Shastri MD, et al. Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation. J Funct Foods. 2019;52:100-108.doi:10.1016/j.jff.2018.10.031
8. Elisashvili V, Kachlishvili E, Chikindas ML. Recent advances in the physiology of spore formation for Bacillus probiotic production. Probiotics Antimicrob Proteins. 2019;11(3):731-747. doi:10.1007/s12602-018-9492-x
9. Tang R, Li L. Modulation of short-chain fatty acids as potential therapy method for type 2 diabetes mellitus. Can J Infect Dis Med Microbiol J Can Mal Infect Microbiol Médicale. 2021;2021:6632266. doi:10.1155/2021/6632266
10. Portincasa P, Bonfrate L, Vacca M, et al. Gut microbiota and short chain fatty acids: implications in glucose homeostasis. Int J Mol Sci. 2022;23(3):1105. doi:10.3390/ijms23031105
11. Zhang HL, Li WS, Xu DN, et al. Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice. Exp Ther Med. 2016;12(4):2554-2562.doi:10.3892/etm.2016.3686
12. Ilinskaya ON, Ulyanova VV, Yarullina DR, Gataullin IG. Secretome of intestinal bacilli: a natural guard against pathologies. Front Microbiol. 2017;8:1666. doi:10.3389/fmicb.2017.01666
13. Ripert G, Racedo SM, Elie AM, Jacquot C, Bressollier P, Urdaci MC. Secreted compounds of the probiotic Bacillus clausii strain O/C inhibit the cytotoxic effects induced by Clostridium difficile and Bacillus cereus toxins. Antimicrob Agents Chemother. 2016;60(6):3445-3454. doi:10.1128/AAC.02815-15
14. Labellarte G, Maher M. Tolerance and effect of a probiotic supplement delivered in capsule form. Food Nutr Sci.2019;10(06):626-634. doi:10.4236/fns.2019.106046
15. Cuentas AM, Deaton J, Khan S, Davidson J, Ardita C. The effect of Bacillus subtilis DE111 on the daily bowel movement profile for people with occasional gastrointestinal irregularity. J Probiotics Health. 2017;05(04).doi:10.4172/2329-8901.1000189
16. Majeed M, Nagabhushanam K, Natarajan S, et al. Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant irritable bowel syndrome: a double blind randomized placebo controlled pilot clinical study. Nutr J. 2015;15(1):21. doi:10.1186/s12937-016-0140-6
17. Majeed M, Nagabhushanam K, Arumugam S, Majeed S, Ali F. Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study. Food Nutr Res. 2018;62(0). doi:10.29219/fnr.v62.1218
18. Abhari K, Shekarforoush SS, Hosseinzadeh S, Nazifi S, Sajedianfard J, Eskandari
MH. The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats. Food Nutr Res. 2016;60(1):30876. doi:10.3402/fnr.v60.30876
19. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci. 2021;22(5):2453. doi:10.3390/ijms22052453
20. Rhayat L, Maresca M, Nicoletti C, et al. Effect of Bacillus subtilis strains on intestinal barrier function and inflammatory response. Front Immunol. 2019;10:564. doi:10.3389/fimmu.2019.00564
21. Townsend JR, Bender D, Vantrease WC, et al. Effects of probiotic (Bacillus subtilis DE111) supplementation on immune function, hormonal status, and physical performance in Division I baseball players. Sports Basel Switz. 2018;6(3):70. doi:10.3390/sports6030070

FDA Disclaimer

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1 review for Immune Support Probiotic*

  1. Stacey Kruger (verified owner)

    I have used St. Healthy Probiotic for a few months, then quit because of the cost. I then have tried several other brands but NONE of them made me feel so regular like St. Healthy! I came crawling back after so many months of no success! This product is amazing.

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